Diagnostic values of glial fibrillary acidic protein, neuron-specific enolase and protein S100β for sepsis-associated encephalopathy

Abstract Background To investigate the expressions of glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE) and S100β their diagnostic values for sepsis-associated encephalopathy (SAE). Methods One hundred patients with sepsis treated from August 2021 to 2022 were included. They assigned a group (n=65) an SAE (n=35), while 50 healthy volunteers physically examined in same period enrolled as control group. The levels GFAP NSE detected by enzyme-linked immunosorbent assay, that was determined transmitted immunoturbidimetric assay. GFAP, detected, correlations analyzed. Results Compared mild moderate SAE, those severe had higher (P<0.05). coma than consciousness disturbance, they poor prognosis good Positive identified between (r=0.573, P=0.001), (r=0.468, P=0.005), (r=0.540, P=0.001) expression SAE. alone, combination sensitivity lower specificity diagnosing Conclusions There are among S100β, combined detection these three indicators is highly valuable diagnosis